Phospholipides and adrenaline secretion in guinea pig adrenal medulla.

Stimulation by appropriate agents of protein and polypeptide secretion in various glands is accompanied by an increased turnover of P32 in phospholipides; the effect is greatest in phosphoinositide and phosphatidic acid (l-5). To establish whether the phospholipide effect is confined to protein and polypeptide secretion or whether it may also be concerned with the secretion of smaller molecules, adrenaline secretion has been stimulated with acetylcholme in slices from guinea pigadrenal medulla, and the incorporation of Ps2 into the phospholipides has been studied. Increased secretion of adrenaline is accompanied by an increased incorporation of Ps2 into the phospholipides; again the effect is greatest in phosphoinositide and phosphatidic acid.